Haematopoiesis represent the best characterised adult stem cell system and continues to provide important paradigms for understanding other stem cells as well as cancer biology. the focus of this group continues to be the transcriptional regulation of blood stem cells, and the mechanisms whereby such stem cells are subverted to form leukaemias. Current research programmes include:
- Myeloproliferative neoplasms, JAK/StAt signalling and stem cell subversion (Professor Green).
- Transcriptional networks regulating blood stem cells (Professor Göttgens).
- The pathogenesis of bone marrow failure syndromes and leukaemia (Professor Warren).
- The biology of leukaemia stem cells (Dr Huntly).
- The developmental origin of haematopoietic stem cells (Dr Ottersbach).