- MRC: Regenerative Medicine Research Committee (Apr 2014-Apr 2017) “Recreating the 3D niche for efficient platelet production in vitro under GMP conditions” (£1.2m). Lead PI on the grant, collaboration with the Wellcome Trust Sanger Institute (Dr Gavin Wright) to generate a library of ectodomain recombinant proteins for the functionalisation of 3D scaffolds to promote platelet production in vitro from pluripotent stem cells-derived megakaryocytes.
- NHSBT Trust Fund (Apr 2014-Dec 2015) “Identification of novel drivers of platelet release in plateletpheresis donors” (50k). Dynamic serial platelet counts and immature platelet fraction analysis post-apheresis donation combined with mass spectrometry proteomics of plasma samples to identify novel plasma-derived growth factors that promote platelet production.
- NHSBT Trust Fund (Apr 2014-Dec 2015) “Genetic manipulation of human induced pluripotent stem cells to remove HLA Class I explression for in vitro production of universal platelet concentrates” (50k).
- NHSBT Trust Fund (Mar 2015-Jul 2016) “Bedside platelet function testing to guide the use of platelet transfusion in neonates” (50k).
- British Heart Foundation Project Grant (Jan 2014-Dec 2016) “Defining the function of novel regulators of platelet formation”, co-applicant (£152k). Setting up mouse models for preclinical validation of in vitro derived megakaryocytes and platelets.
- British Heart Foundation (Oct 2014-Sep 2017) “Cytokine receptor-like factor 3 (CRLF3): a novel target for prevention of cardiovascular events in patients with thrombocythaemia” (£160k).
- Wellcome Trust Translational Grant (BloodPharma) (Nov 2013-Nov 2016) “Scalable in vitro production of red cells for clinical transfusion”, consortium led by Scottish National Blood service (£4.8m, £500k to the Ghevaert group). The Ghevaert group is charged with the identification of differentially expressed transcription factors based on “omics” data from adult- and pluripotent stem cells-derived red cells. We will use a cellular reprogramming strategy for the adequate maturation of red cells in vitro including adult globin switching and efficient enucleation.
- NIHR programme grant (Oct 2010-Oct 2015) “Megakaryocyte and platelet biology and genomics”, Prof W H Ouwehand Programme Director (£3.5m, £1.2m to the Ghevaert group). The Ghevaert group concentrates on the delivery of 2 work packages: efficient derivation of megakaryocytes from pluripotent stem cells through a cellular reprogramming strategy and setting up the basic technology for 3D scaffolds and functionalisation with recombinant protein for platelet production in vitro.