Professor of Haematology
Description of research
The current focus of our laboratory is to elucidate the fundamental conserved molecular mechanisms that control ribosome maturation and to understand how defects in this process result in cancer predisposition. Using a multidisciplinary approach, we combine genetic approaches in model organisms with high-resolution structural studies using NMR spectroscopy, X-ray crystallography and cryo-EM. Our long-term goal is to use the insights obtained from our studies to develop novel approaches to cancer therapy.
Keywords: Ribosome biogenesis, Stem cells, Genetics, Structural biology, RNA processing
Clinical conditions: Myelodysplastic syndromes, Leukaemia, Inherited bone marrow failure syndromes, Shwachman-Diamond syndrome, Poikiloderma with neutropenia
Methodologies: Model organisms (Drosophila, yeast, Dictyostelium), mammalian genetics, confocal microscopy, X-ray crystallography, NMR spectroscopy, Cryo-EM, protein expression and purification, molecular biology, biochemistry