BloodCounts! breakthrough in disease detection 1 of 6
Uncovering the regulatory blueprint for early mammalian organ formation 2 of 6
Targeting nearby ‘normal’ cells could improve survival rates 3 of 6
Insight into the development of lymphoma 4 of 6
A BLUEPRINT for blood cells: major epigenetic study 5 of 6
Life-saving discovery and commercial success 6 of 6
The University of Cambridge Department of Haematology is located at the Cambridge Biomedical Campus and the Wellcome Trust Genome Campus. It has laboratories in the Jeffrey Cheah Biomedical Centre, the Cambridge Institute for Medical Research, NHS Blood and Transplant Blood Centre and the Wellcome Sanger Institute. The Head of Department is Professor Brian Huntly.
The department has four main goals:
- To conduct internationally competitive biomedical research.
- To provide education in medical aspects of haematology to undergraduate scientists and medical students.
- To provide postgraduate education, largely through the provision of PhD students.
- To contribute to the clinical activities of the Addenbrooke's Department of Haematology.
Recent publications
Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin NW, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Filipa Domingues A, Vassiliou G, Sano S, Walsh K. The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Circ Res. 2021 Jul 28.
Liang G, Zhou C, Jiang X, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B, Wang H, Han JJ, Liu F. De novo generation of macrophage from placenta-derived hemogenic endothelium. Dev Cell. 2021 Jul 26;56(14):2121-2133.e6.
Prados B, Del Toro R, MacGrogan D, Gómez-Apiñániz P, Papoutsi T, Muñoz-Cánoves P, Méndez-Ferrer S, de la Pompa JL. Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages. Cell Death Dis. 2021 Jul 22;12(8):729.
Mabuchi Y, Okawara C, Méndez-Ferrer S, Akazawa C. Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow. Front Cell Dev Biol. 2021 Jul 6;9:689366.
Spencer Chapman M, Ranzoni AM, Myers B, Williams N, Coorens THH, Mitchell E, Butler T, Dawson KJ, Hooks Y, Moore L, Nangalia J, Robinson PS, Yoshida K, Hook E, Campbell PJ, Cvejic A. Lineage tracing of human development through somatic mutations. Nature. 2021 Jul;595(7865):85-90.
Barile M, Imaz-Rosshandler I, Inzani I, Ghazanfar S, Nichols J, Marioni JC, Guibentif C, Göttgens B. Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation. Genome Biol. 2021 Jul 5;22(1):197.
Maifrede S, ... Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T. TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Cancer Res. 2021 Jul 2:canres.3761.2020.
Hatti KS, McCoy AJ, Read RJ. Likelihood-based estimation of substructure content from single-wavelength anomalous diffraction (SAD) intensity data. Acta Crystallogr D Struct Biol. 2021 Jul 1;77(Pt 7):880-893.
Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, Cheng Y, Pellegrino S, Warren AJ, Paralkar VR, Tong W. HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell. 2021 Jul 1.
Chen J, Sathiaseelan V, Moore A, Tan S, Chilamakuri CSR, Roamio Franklin VN, Shahsavari A, Jakwerth CA, Hake SB, Warren AJ, Mohorianu I, D'Santos C, Ringshausen I. ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. Blood. 2021 Jul 1;137(26):3629-3640.
Rossi M, ... Vassiliou G, Haferlach T, Lucca U, Della Porta MG. Clinical relevance of clonal hematopoiesis in the oldest-old population. Blood. 2021 Jun 14:blood.2021011320.
Ecker V, Stumpf M, Brandmeier L, Neumayer T, Pfeuffer L, Engleitner T, Ringshausen I, Nelson N, Jücker M, Wanninger S, Zenz T, Wendtner C, Manske K, Steiger K, Rad R, Müschen M, Ruland J, Buchner M. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia. Nat Commun. 2021 Jun 10;12(1):3526.
Oedekoven CA, Belmonte M, Bode D, Hamey FK, Shepherd MS, Che JLC, Boyd G, McDonald C, Belluschi S, Diamanti E, Bastos HP, Bridge KS, Göttgens B, Laurenti E, Kent DG. Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures. Stem Cell Reports. 2021 Jun 8;16(6):1614-1628.
Tangherloni A, Ricciuti F, Besozzi D, Liò P, Cvejic A. Analysis of single-cell RNA sequencing data based on autoencoders. BMC Bioinformatics. 2021 Jun 8;22(1):309.
Thoms JAI, Truong P, Subramanian S, Knezevic K, Harvey G, Huang Y, Seneviratne JA, Carter DR, Joshi S, Skhinas J, Chacon D, Shah A, de Jong I, Beck D, Gottgens B, Larsson J, Wong JWH, Zanini F, Pimanda JE. Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. Blood. 2021 Jun 1:blood.2020009707.
Goudswaard LJ, Bell JA, Hughes DA, Corbin LJ, Walter K, Davey Smith G, Soranzo N, Danesh J, Di Angelantonio E, Ouwehand WH, Watkins NA, Roberts DJ, Butterworth AS, Hers I, Timpson NJ. Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates. Int J Obes (Lond). 2021 Jul 5.
Puan KJ, San Luis B, Yusof N, Kumar D, Andiappan AK, Lee W, Cajic S, Vuckovic D, Chan J, Döllner T, Hou HW, Jiang Y, Tian C; 23andMe Research Team, Rapp E, Poidinger M, Wang Y, Soranzo N, Lee B, Rötzschke O. FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression. Commun Biol. 2021 Jul 2;4(1):832.
Hu Y, ... Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am J Hum Genet. 2021 Jun 3;108(6):1165.
Young AMH, ... Soranzo N, Bayraktar OA, Stevens B, Hutchinson PJ, Franklin RJM, Gaffney DJ. A map of transcriptional heterogeneity and regulatory variation in human microglia. Nat Genet. 2021 Jun;53(6):861-868.
Richardson SE, Huntly BJP. Targeting Chromatin Regulation in Acute Myeloid Leukemia. Hemasphere. 2021 Jun 1;5(6):e589.
Cao H, Neerincx A, de Bono B, Lakner U, Huntington C, Elvin J, Gudgin E, Pridans C, Vickers MA, Huntly B, Trowsdale J, Barrow AD. Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells. Br J Haematol. 2021 Jun;193(5):946-950.
The NIHR BioResource is a panel of volunteers, with and without health conditions, who will participate in research studies investigating the links between genes, the environment, health and disease enabling scientific discoveries as well as facilitating translational medicine for the benefit of patients.They donate their DNA via a blood or saliva sample which is used together with other information, such as gender, ethnicity, lifestyle and health information to match them to specific research studies. The NIHR Cambridge Centre is one of 13 centres which make up the NIHR BioResource.
Cambridge Blood and Stem Cell BioBank
The Cambridge Blood and Stem Cell Biobank is a tissue bank for samples from patients with haematological malignancies and normal individuals, including cord blood. We are also the repository for the UK Myeloproliferative Disorders (MPD) sample bank, and several clinical trials for this group of disorders. The bank has collected over 15,000 blood and bone marrow-derived samples to date from patients with haematological malignancies and approximately 2600 normal individuals, all curated in a bespoke database designed to facilitate research activities. Existing samples and prospective collections are available to researchers working on ethically approved studies in malignant blood disorders and normal blood development, and 4800 samples have been transferred to researchers both in the UK and internationally.
Haematology at Cambridge