BloodCounts! breakthrough in disease detection 1 of 6
Uncovering the regulatory blueprint for early mammalian organ formation 2 of 6
Targeting nearby ‘normal’ cells could improve survival rates 3 of 6
Insight into the development of lymphoma 4 of 6
A BLUEPRINT for blood cells: major epigenetic study 5 of 6
Life-saving discovery and commercial success 6 of 6
The University of Cambridge Department of Haematology is located at the Cambridge Biomedical Campus and the Wellcome Trust Genome Campus. It has laboratories in the Jeffrey Cheah Biomedical Centre, the Cambridge Institute for Medical Research, NHS Blood and Transplant Blood Centre and the Wellcome Sanger Institute. The Head of Department is Professor Brian Huntly.
The department has four main goals:
- To conduct internationally competitive biomedical research.
- To provide education in medical aspects of haematology to undergraduate scientists and medical students.
- To provide postgraduate education, largely through the provision of PhD students.
- To contribute to the clinical activities of the Addenbrooke's Department of Haematology.
Recent publications
Hematopoietic stem and progenitor cells outside the bone marrow: where, when, and why. Exp Hematol. 2021 Dec;104:9-16.
The EHA Research Roadmap: Normal Hematopoiesis. Hemasphere. 2021 Nov 30;5(12):e669.
Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes. Blood. 2021 Nov 18;138(20):1998-2001.
CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation. Stem Cell Reports. 2021 Nov 9;16(11):2784-2797.
Severe congenital neutropenia with elastase, neutrophil expressed (ELANE) gene mutation in a Tanzanian child. Br J Haematol. 2021 Nov 1.
KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia. Blood Adv. 2021 Oct 15:bloodadvances.2020002842.
Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients. Cell Stem Cell. 2021 Oct 7;28(10):1683-1685.
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression. Nat Genet. 2021 Oct;53(10):1443-1455.
The NIHR BioResource is a panel of volunteers, with and without health conditions, who will participate in research studies investigating the links between genes, the environment, health and disease enabling scientific discoveries as well as facilitating translational medicine for the benefit of patients.They donate their DNA via a blood or saliva sample which is used together with other information, such as gender, ethnicity, lifestyle and health information to match them to specific research studies. The NIHR Cambridge Centre is one of 13 centres which make up the NIHR BioResource.
Cambridge Blood and Stem Cell BioBank
The Cambridge Blood and Stem Cell Biobank is a tissue bank for samples from patients with haematological malignancies and normal individuals, including cord blood. We are also the repository for the UK Myeloproliferative Disorders (MPD) sample bank, and several clinical trials for this group of disorders. The bank has collected over 15,000 blood and bone marrow-derived samples to date from patients with haematological malignancies and approximately 2600 normal individuals, all curated in a bespoke database designed to facilitate research activities. Existing samples and prospective collections are available to researchers working on ethically approved studies in malignant blood disorders and normal blood development, and 4800 samples have been transferred to researchers both in the UK and internationally.
Haematology at Cambridge