Uncovering the regulatory blueprint for early mammalian organ formation 1 of 5
Targeting nearby ‘normal’ cells could improve survival rates 2 of 5
Insight into the development of lymphoma 3 of 5
A BLUEPRINT for blood cells: major epigenetic study 4 of 5
Life-saving discovery and commercial success 5 of 5
The University of Cambridge Department of Haematology is located at the Cambridge Biomedical Campus and the Wellcome Trust Genome Campus. It has laboratories in the Jeffrey Cheah Biomedical Centre, the Cambridge Institute for Medical Research, NHS Blood and Transplant Blood Centre and the Wellcome Sanger Institute. The Head of Department is Professor Brian Huntly.
The department has four main goals:
- To conduct internationally competitive biomedical research.
- To provide education in medical aspects of haematology to undergraduate scientists and medical students.
- To provide postgraduate education, largely through the provision of PhD students.
- To contribute to the clinical activities of the Addenbrooke's Department of Haematology.
Recent publications
Dobson R, Du PY, Rásó-Barnett L, Yao WQ, Chen Z, Casa C, Ei-Daly H, Farkas L, Soilleux E, Wright P, Grant JW, Rodriguez-Justo M, Follows GA, Rashed H, Fabre M, Baxter EJ, Vassiliou G, Wotherspoon A, Attygalle AD, Liu H, Du MQ. Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis. Haematologica. 2021 Feb 11.
Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A, Timms P, Carter RN, Allen L, Campos J, Vukovic M, Guitart AV, Giles P, O'Shea M, Vernimmen D, Morton NM, Rodrigues NP, Göttgens B, Schofield CJ, Lengeling A, O'Carroll D, Kranc KR. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Adv. 2021 Feb 9;5(3):889-899. 2
Caballero I, Sammito MD, Afonine PV, Usón I, Read RJ, McCoy AJ. Detection of translational noncrystallographic symmetry in Patterson functions. Acta Crystallogr D Struct Biol. 2021 Feb 1;77(Pt 2):131-141.
Bell S, ... Soranzo N, ... Ouwehand WH, ... Stefansson K. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Commun Biol. 2021 Feb 3;4(1):156.
Usón I, Ballard CC, Keegan RM, Read RJ. Integrated, rational molecular replacement. Acta Crystallogr D Struct Biol. 2021 Feb 1;77(Pt 2):129-130.
Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N, Trumpp A. Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. Nat Commun. 2021 Jan 27;12(1):608.
Caeser R, Walker I, Gao J, Shah N, Rasso-Barnett L, Anand S, Martin JE, Hodson DJ. Acquired CARD11 mutation promotes BCR independence in Diffuse Large B Cell Lymphoma. JCO Precis Oncol. 2021;5:145-152.
Aarts CEM, Downes K, Hoogendijk AJ, Sprenkeler EGG, Gazendam RP, Favier R, Favier M, Tool ATJ, van Hamme JL, Kostadima MA, Waller K, Zieger B, van Bergen MGJM, Langemeijer SMC, van der Reijden BA, Janssen H, van den Berg TK, van Bruggen R, Meijer AB, Ouwehand WH, Kuijpers TW. Neutrophil specific granule and NETosis defects in gray platelet syndrome. Blood Adv. 2021 Jan 26;5(2):549-564.
Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Rejtö J, Ouwehand WH, Downes K, Haimel M, Pabinger I, Gebhart J. Elevated levels of tissue factor pathway inhibitor in patients with mild to moderate bleeding tendency. Blood Adv. 2021 Jan 26;5(2):391-398.
Harland LTG, Simon CS, Senft AD, Costello I, Greder L, Imaz-Rosshandler I, Göttgens B, Marioni JC, Bikoff EK, Porcher C, de Bruijn MFTR, Robertson EJ. The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nat Cell Biol. 2021 Jan;23(1):61-74.
Dingsdale H, Nan X, Garay SM, Mueller A, Sumption LA, Chacón-Fernández P, Martinez-Garay I, Ghevaert C, Barde YA, John RM. The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor. Transl Psychiatry. 2021 Jan 18;11(1):62.
Guibentif C, Griffiths JA, Imaz-Rosshandler I, Ghazanfar S, Nichols J, Wilson V, Göttgens B, Marioni JC. Diverse Routes toward Early Somites in the Mouse Embryo. Dev Cell. 2021 Jan 11;56(1):141-153.e6.
Rothenberg EV, Göttgens B. How haematopoiesis research became a fertile ground for regulatory network biology as pioneered by Eric Davidson. Curr Opin Hematol. 2021 Jan;28(1):1-10.
Wang X, Peticone C, Kotsopoulou E, Göttgens B, Calero-Nieto FJ. Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures. Oncoimmunology. 2021 Jan 6;10(1):1866287.
McCoy AJ, Stockwell DH, Sammito MD, Oeffner RD, Hatti KS, Croll TI, Read RJ. Phasertng: directed acyclic graphs for crystallographic phasing. Acta Crystallogr D Struct Biol. 2021 Jan 1;77(Pt 1):1-10.
The NIHR BioResource is a panel of volunteers, with and without health conditions, who will participate in research studies investigating the links between genes, the environment, health and disease enabling scientific discoveries as well as facilitating translational medicine for the benefit of patients.They donate their DNA via a blood or saliva sample which is used together with other information, such as gender, ethnicity, lifestyle and health information to match them to specific research studies. The NIHR Cambridge Centre is one of 13 centres which make up the NIHR BioResource.
Cambridge Blood and Stem Cell BioBank
The Cambridge Blood and Stem Cell Biobank is a tissue bank for samples from patients with haematological malignancies and normal individuals, including cord blood. We are also the repository for the UK Myeloproliferative Disorders (MPD) sample bank, and several clinical trials for this group of disorders. The bank has collected over 15,000 blood and bone marrow-derived samples to date from patients with haematological malignancies and approximately 2600 normal individuals, all curated in a bespoke database designed to facilitate research activities. Existing samples and prospective collections are available to researchers working on ethically approved studies in malignant blood disorders and normal blood development, and 4800 samples have been transferred to researchers both in the UK and internationally.
Cambridge Blood and Stem Cell Biobank