Haematopoiesis represent the best characterised adult stem cell system and continues to provide important paradigms for understanding other stem cells as well as cancer biology. The focus of this group continues to be the transcriptional regulation of blood stem cells, and the mechanisms whereby such stem cells are subverted to form leukaemias. Current research programmes include:
- Myeloproliferative neoplasms, JAK/STAT signalling and stem cell subversion (Tony Green).
- Transcriptional networks regulating blood stem cells (Bertie Göttgens).
- Pathogenesis of bone marrow failure syndromes, the ribosomopathies and leukaemia (Alan Warren).
- The biology of leukaemia stem cells (Brian Huntly).
- Regulation of haematopoiesis in homeostasis and disease (Ana Cvejic).
- Chronic lymphocytic leukaemia (Ingo Ringshausen).
- Haematopoietic stem cells (Elisa Laurenti).
- Pathogenesis of germinal centre derived B cell lymphomas (Dan Hodson).