Professor Bertie Göttgens

Key Publications

• Azami T, Theeuwes B, Nu Ton ML, Mansfield W, Harland L, Kinoshita M, Gottgens B, Nichols J. STAT3 signaling enhances tissue expansion during postimplantation mouse development. Cell Rep. 2025 Apr 5;44(4):115506.
• Toghani D, Gupte S, Zeng S, Mahammadov E, Crosse EI, Seyedhassantehrani N, Burns C, Gravano D, Radtke S, Kiem HP, Rodriguez S, Carlesso N, Pradeep A, Georgiades A, Lucas F, Wilson NK, Kinston SJ, Göttgens B, Zong L, Beerman I, Park B, Janssens DH, Jones D, Toghani A, Nerlov C, Pietras EM, Mesnieres M, Maes C, Kumanogoh A, Worzfeld T, Cheong JG, Josefowicz SZ, Kharchenko P, Scadden DT, Scialdone A, Spencer JA, Silberstein L. Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells. Nat Aging. 2025 Jan 29.
• Cui B, Ai L, Lei M, Duan Y, Tang C, Zhang J, Gao Y, Li X, Zhu C, Zhang Y, Zhu X, Isobe T, Yang W, Gottgens B, Zhu P. Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia. Blood. 2025 Mar 13;145(11):1211-1224.
• Williams MJ, Wang X, Bastos HP, Grondys-Kotarba G, Wu Q, Jin S, Johnson CS, Mende N, Calderbank EF, Wantoch M, Park HJ, Mantica G, Hannah RL, Wilson NK, Pask DC, Hamilton TL, Kinston SJ, Asby R, Sneade R, Baxter EJ, Campbell PJ, Vassiliou GS, Laurenti E PhD, Li J, Gottgens B, Green AR. Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition. Blood Adv. 2024 Oct 7:bloodadvances.2024014046.
• Xiang G, He X, Giardine BM, Isaac KJ, Taylor DJ, McCoy RC, Jansen C, Keller CA, Wixom AQ, Cockburn A, Miller A, Qi Q, He Y, Li Y, Lichtenberg J, Heuston EF, Anderson SM, Luan J, Vermunt MW, Yue F, Sauria MEG, Schatz MC, Taylor J, Göttgens B, Hughes JR, Higgs DR, Weiss MJ, Cheng Y, Blobel GA, Bodine DM, Zhang Y, Li Q, Mahony S, Hardison RC. Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Genome Res. 2024 Aug 20;34(7):1089-1105.
• Johnson CS, Williams MJ, Sham K, Belluschi S, Ma W, Wang X, Lau WW, Kaufmann K, Krivdova G, Calderbank EF, Mende N, McLeod J, Mantica G, Li J, Grey-Wilson C, Drakopoulos M, Basheer S, Sinha S, Diamanti E, Basford C, Wilson NK, Howe SJ, Dick JE, Gottgens B, Green AR, Francis N, Laurenti E. Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of cell cycle. Blood. 2024 Aug 15;144(7):729-741.
• Dellorusso PV, Proven MA, Calero-Nieto FJ, Wang X, Mitchell CA, Hartmann F, Amouzgar M, Favaro P, DeVilbiss A, Swann JW, Ho TT, Zhao Z, Bendall SC, Morrison S, Göttgens B, Passegué E. Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells. Cell Stem Cell. 2024 May 13:S1934-5909(24)00174-7.
• Xu J, Guo P, Hao S, Shangguan S, Shi Q, Volpe G, Huang K, Zuo J, An J, Yuan Y, Cheng M, Deng Q, Zhang X, Lai G, Nan H, Wu B, Shentu X, Wu L, Wei X, Jiang Y, Huang X, Pan F, Song Y, Li R, Wang Z, Liu C, Liu S, Li Y, Yang T, Xu Z, Du W, Li L, Ahmed T, You K, Dai Z, Li L, Qin B, Li Y, Lai L, Qin D, Chen J, Fan R, Li Y, Hou J, Ott M, Sharma AD, Cantz T, Schambach A, Kristiansen K, Hutchins AP, Göttgens B, Maxwell PH, Hui L, Xu X, Liu L, Chen A, Lai Y, Esteban MA. A spatiotemporal atlas of mouse liver homeostasis and regeneration. Nat Genet. 2024 May;56(5):953-969.
• Hanson AL, Mulè MP, Ruffieux H, Mescia F, Bergamaschi L, Pelly VS, Turner L, Kotagiri P, Cambridge Institute of Therapeutic Immunology and Infectious Disease–National Institute for Health Research (CITIID–NIHR) COVID BioResource Collaboration, Göttgens B, Hess C, Gleadall N, Bradley JR, Nathan JA, Lyons PA, Drakesmith H, Smith KGC. Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nat Immunol. 2024 Mar;25(3):471-482.
• Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guillén Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang X, Calero-Nieto FJ, Esteller M, Florian MC, Porta E, Benedito R, Göttgens B, Lacaud G, Espinosa L, Bigas A. Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate. Nat Commun. 2024 Feb 21;15(1):1604.
• Kucinski I, Campos J, Barile M, Severi F, Bohin N, Moreira PN, Allen L, Lawson H, Haltalli MLR, Kinston SJ, O'Carroll D, Kranc KR, Göttgens B. A time- and single-cell-resolved model of murine bone marrow hematopoiesis. Cell Stem Cell. 2024 Feb 1;31(2):244-259.e10.
• Schulz M, Teissandier A, De La Mata Santaella E, Armand M, Iranzo J, El Marjou F, Gestraud P, Walter M, Kinston S, Göttgens B, Greenberg MVC, Bourc'his D. DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation. Nat Struct Mol Biol. 2024 Jan 4.
• Ban M, Bredikhin D, Huang Y, Bonder MJ, Katarzyna K, Oliver AJ, Wilson NK, Coupland P, Hadfield J, Göttgens B, Madissoon E, Stegle O, Sawcer S. “Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis” Brain. 2023 Dec 1:awad404
• Imaz-Rosshandler I, Rode C, Guibentif C, Harland LTG, Ton MN, Dhapola P, Keitley D, Argelaguet R, Calero-Nieto FJ, Nichols J, Marioni JC, de Bruijn MFTR, Göttgens B. “Tracking early mammalian organogenesis – prediction and validation of differentiation trajectories at whole organism scale” Development. 2023 Nov 17:dev.201867.
• Subramanian S, Thoms JAI, Huang Y, Cornejo Paramo CP, Koch FC, Jacquelin S, Shen S, Song E, Joshi S, Brownlee CP, Woll PS, Chacon-Fajardo D, Beck D, Curtis DJ, Yehson K, Antonenas V, O’Brien T, Trickett A, Powell JA, Lewis ID, Pitson SM, Gandhi MK, Lane SW, Vafaee F, Wong E, Gottgens B, Rokny H, Wong JWH, Pimanda JE. “Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC” Blood. 2023 Aug 18:blood.2023021120.
• Goh I, Botting RA, Rose A, Webb S, Engelbert J, Gitton Y, Stephenson E, Quiroga Londoño M, Mather M, Mende N, Imaz-Rosshandler I, Yang L, Horsfall D, Basurto-Lozada D, Chipampe NJ, Rook V, Lee JTH, Ton ML, Keitley D, Mazin P, Vijayabaskar MS, Hannah R, Gambardella L, Green K, Ballereau S, Inoue M, Tuck E, Lorenzi V, Kwakwa K, Alsinet C, Olabi B, Miah M, Admane C, Popescu DM, Acres M, Dixon D, Ness T, Coulthard R, Lisgo S, Henderson DJ, Dann E, Suo C, Kinston SJ, Park JE, Polanski K, Marioni J, van Dongen S, Meyer KB, de Bruijn M, Palis J, Behjati S, Laurenti E, Wilson NK, Vento-Tormo R, Chédotal A, Bayraktar O, Roberts I, Jardine L, Göttgens B, Teichmann SA, Haniffa M. “Yolk sac cell atlas reveals multiorgan functions during human early development” Science. 2023 Aug 18;381(6659):eadd7564.
• Sturgess K, Yankova E, Vijayabaskar MS, Isobe T, Rak J, Kucinski I, Barile M, Webster NA, Eleftheriou M, Hannah R, Gozdecka M, Vassiliou G, Rausch O, Wilson NK, Göttgens B, Tzelepis K. “Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages” Leukemia. 2023 Jul 19.
• Wang M, Brandt LTL, Wang X, Russell H, Mitchell E, Kamimae-Lanning AN, Brown JM, Dingler FA, Garaycoechea JI, Isobe T, Kinston SJ, Gu M, Vassiliou GS, Wilson NK, Göttgens B, Patel KJ. “Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner” Mol Cell. 2023 Jun 15:S1097-2765(23)00419-7.
• Ton MN, Keitley D, Theeuwes B, Guibentif C, Ahnfelt-Rønne J, Andreassen TK, Calero-Nieto FJ, Imaz-Rosshandler I, Pijuan-Sala B, Nichols J, Benito-Gutiérrez È, Marioni JC, Göttgens B. “An atlas of rabbit development as a model for single-cell comparative genomics” Nat Cell Biol. 2023 Jul;25(7):1061-1072.
• Kumasaka N, Rostom R, Huang N, Polanski K, Meyer KB, Patel S, Boyd R, Gomez C, Barnett SN, Panousis NI, Schwartzentruber J, Ghoussaini M, Lyons PA, Calero-Nieto FJ, Göttgens B, Barnes JL, Worlock KB, Yoshida M, Nikolić MZ, Stephenson E, Reynolds G, Haniffa M, Marioni JC, Stegle O, Hagai T, Teichmann SA. “Mapping interindividual dynamics of innate immune response at single-cell resolution” Nat Genet. 2023 Jun;55(6):1066-1075.
• Potts M, Fletcher-Etherington A, Nightingale K, Mescia F, Bergamaschi L, Calero-Nieto FJ, Antrobus R, Williamson J; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Parsons H, Huttlin EL, Kingston N, Göttgens B, Bradley JR, Lehner PJ, Matheson NJ, Smith KGC, Wills MR, Lyons PA, Weekes MP. “Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity” Cell Rep. 2023 May 29;42(6):112613.
• Edginton-White B, Maytum A, Kellaway SG, Goode DK, Keane P, Pagnuco I, Assi SA, Ames L, Clarke M, Cockerill PN, Göttgens B, Cazier JB, Bonifer C. “A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification” Nat Commun. 2023 Jan 17;14(1):267.
• Mitchell CA, Verovskaya EV, Calero-Nieto FJ, Olson OC, Swann JW, Wang X, Hérault A, Dellorusso PV, Zhang SY, Svendsen AF, Pietras EM, Bakker ST, Ho TT, Göttgens B, Passegué E. “Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing” Nat Cell Biol. 2023 Jan;25(1):30-41.
• Lewis JE, Woodward OR, Nuzzaci D, Smith CA, Adriaenssens AE, Billing L, Brighton C, Phillips BU, Tadross JA, Kinston SJ, Ciabatti E, Göttgens B, Tripodi M, Hornigold D, Baker D, Gribble FM, Reimann F. “Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice” Mol Metab. 2022 Dec;66:101604
• Sturgess KH, Wilson NK, Gottgens B. “Single Cell Genomics – a new chapter in how technological advances propel Hemato-Oncology” Blood. 2022 Sep 14:blood.2022017361.
• Wehling A, Loeffler D, Zhang Y, Kull T, Donato C, Szczerba BM, Camargo Ortega G, Lee M, Moor A, Gottgens B, Aceto N, Schroeder T. “Combined single-cell tracking and omics improves blood stem cell fate regulator identification” Blood. 2022 Jul 12:blood.2022016880.
• Lin X, Swedlund B, Ton MN, Ghazanfar S, Guibentif C, Paulissen C, Baudelet E, Plaindoux E, Achouri Y, Calonne E, Dubois C, Mansfield W, Zaffran S, Marioni JC, Fuks F, Göttgens B, Lescroart F, Blanpain C. “Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors” Nat Cell Biol. 2022 Jul;24(7):1114-1128.
• Li J, Williams MJ, Park HJ, Bastos HP, Wang X, Prins DP, Wilson NK, Johnson C, Sham K, Wantoch M, Watcham S, Kinston SJ, Pask DC, Hamilton TL, Sneade R, Waller AK, Ghevaert C, Vassiliou GS, Laurenti E, Kent DG, Gottgens B, Green AR. “STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resists myeloablation and neoplastic expansion” Blood. 2022 Jun 29:blood.2021014009.
• Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga Londoño M, Sham K, Mantica G, Morishima T, Mitchell E, Lidonnici MR, Meier-Abt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK, Göttgens B, Saeb-Parsy K, Frontini M, Laurenti E. “Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans” Blood. 2022 Jun 9;139(23):3387-3401.
• Kapeni C, Nitsche L, Kilpatrick AM, Wilson NK, Xia K, Mirshelar-Syahkal B, Chandrakanthan V, Malouf C, Pimanda JE, Gottgens B, Kirschner K, Tomlinson S, Ottersbach K. “p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion” Blood. 2022 Jun 2:blood.2021014853.
• Rigo R, Chelbi R, Agopian J, Letard S, Griffon A, Ghamlouch H, Vernerey J, Ladopoulos V, Voisset E, De Sepulveda P, Guittard G, Nunès JA, Bidaut G, Göttgens B, Weber M, Bernard OA, Dubreuil P, Soucie E. “TET2 regulates immune tolerance in chronically activated mast cells” JCI Insight. 2022 Apr 8;7(7):e154191.
• Wang J, Kotagiri P, Lyons PA, Al-Lamki RS, Mescia F, Bergamaschi L, Turner L, Morgan MD, Calero-Nieto FJ, Bach K, Mende N, Wilson NK, Watts ER; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration, Maxwell PH, Chinnery PF, Kingston N, Papadia S, Stirrups KE, Walker N, Gupta RK, Menon DK, Allinson K, Aitken SJ, Toshner M, Weekes MP, Nathan JA, Walmsley SR, Ouwehand WH, Kasanicki M, Göttgens B, Marioni JC, Smith KGC, Pober JS, Bradley JR. “Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19” iScience. 2022 Mar 18;25(3):103971.
• Yoshida M, Worlock KB, Huang N, Lindeboom RGH, Butler CR, Kumasaka N, Dominguez Conde C, Mamanova L, Bolt L, Richardson L, Polanski K, Madissoon E, Barnes JL, Allen-Hyttinen J, Kilich E, Jones BC, de Wilton A, Wilbrey-Clark A, Sungnak W, Pett JP, Weller J, Prigmore E, Yung H, Mehta P, Saleh A, Saigal A, Chu V, Cohen JM, Cane C, Iordanidou A, Shibuya S, Reuschl AK, Herczeg IT, Argento AC, Wunderink RG, Smith SB, Poor TA, Gao CA, Dematte JE; NU SCRIPT Study Investigators, Reynolds G, Haniffa M, Bowyer GS, Coates M, Clatworthy MR, Calero-Nieto FJ, Göttgens B, O’Callaghan C, Sebire NJ, Jolly C, De Coppi P, Smith CM, Misharin AV, Janes SM, Teichmann SA, Nikolić MZ, Meyer KB. “Local and systemic responses to SARS-CoV-2 infection in children and adults” Nature. 2022 Feb;602(7896):321-327.
• Fielding C, García-García A, Korn C, Gadomski S, Fang Z, Reguera JL, Pérez-Simón JA, Göttgens B, Méndez-Ferrer S. “Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis” Nat Commun. 2022 Jan 27;13(1):543.
• Roszak P, Heo JO, Blob B, Toyokura K, Sugiyama Y, de Luis Balaguer MA, Lau WWY, Hamey F, Cirrone J, Madej E, Bouatta AM, Wang X, Guichard M, Ursache R, Tavares H, Verstaen K, Wendrich J, Melnyk CW, Oda Y, Shasha D, Ahnert SE, Saeys Y, De Rybel B, Heidstra R, Scheres B, Grossmann G, Mähönen AP, Denninger P, Göttgens B, Sozzani R, Birnbaum KD, Helariutta Y. “Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization” Science. 2021 Dec 24;374(6575):eaba5531.
• Mende N, Laurenti E, Göttgens B, Wilson NK. “Simultaneous Analysis of Single-Cell Transcriptomes and Cell Surface Protein Expression of Human Hematopoietic Stem Cells and Progenitors Using the 10x Genomics Platform” Methods Mol Biol. 2022;2386:189-201.
• Jaffredo T, Balduini A, Bigas A, Bernardi R, Bonnet D, Canque B, Charbord P, Cumano A, Delwel R, Durand C, Fibbe W, Forrester L, de Franceschi L, Ghevaert C, Gjertsen B, Gottgens B, Graf T, Heidenreich O, Hermine O, Higgs D, Kleanthous M, Klump H, Kouskoff V, Krause D, Lacaud G, Celso CL, Martens JHA, Méndez-Ferrer S, Menendez P, Oostendorp R, Philipsen S, Porse B, Raaijmakers M, Robin C, Stunnenberg H, Theilgaard-Mönch K, Touw I, Vainchenker W, Corrons JV, Yvernogeau L, Schuringa JJ. “The EHA Research Roadmap: Normal Hematopoiesis” Hemasphere. 2021 Nov 30;5(12):e669.
• Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C, Georges E, Martins-Costa C, Sepulveda C, Allen L, Campos J, Campbell KJ, O’Carroll D, Göttgens B, Cory S, Rodrigues NP, Guitart AV, Kranc KR. “CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation” Stem Cell Reports. 2021 Nov 9;16(11):2784-2797.
• Jardine L, Webb S, Goh I, Quiroga Londoño M, Reynolds G, Mather M, Olabi B, Stephenson E, Botting RA, Horsfall D, Engelbert J, Maunder D, Mende N, Murnane C, Dann E, McGrath J, King H, Kucinski I, Queen R, Carey CD, Shrubsole C, Poyner E, Acres M, Jones C, Ness T, Coulthard R, Elliott N, O’Byrne S, Haltalli MLR, Lawrence JE, Lisgo S, Balogh P, Meyer KB, Prigmore E, Ambridge K, Jain MS, Efremova M, Pickard K, Creasey T, Bacardit J, Henderson D, Coxhead J, Filby A, Hussain R, Dixon D, McDonald D, Popescu DM, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Regev A, Behjati S, Laurenti E, Wilson NK, Roy A, Göttgens B, Roberts I, Teichmann SA, Haniffa M. “Blood and immune development in human fetal bone marrow and Down syndrome” Nature. 2021 Oct;598(7880):327-331.
• Haniffa M, Taylor D, Linnarsson S, Aronow BJ, Bader GD, Barker RA, Camara PG, Camp JG, Chédotal A, Copp A, Etchevers HC, Giacobini P, Göttgens B, Guo G, Hupalowska A, James KR, Kirby E, Kriegstein A, Lundeberg J, Marioni JC, Meyer KB, Niakan KK, Nilsson M, Olabi B, Pe’er D, Regev A, Rood J, Rozenblatt-Rosen O, Satija R, Teichmann SA, Treutlein B, Vento-Tormo R, Webb S; Human Cell Atlas Developmental Biological Network. “A roadmap for the Human Developmental Cell Atlas” Nature. 2021 Sep;597(7875):196-205.
• Lohoff T, Ghazanfar S, Missarova A, Koulena N, Pierson N, Griffiths JA, Bardot ES, Eng CL, Tyser RCV, Argelaguet R, Guibentif C, Srinivas S, Briscoe J, Simons BD, Hadjantonakis AK, Göttgens B, Reik W, Nichols J, Cai L, Marioni JC. “Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis” Nat Biotechnol 2021 Sep 6.
• Gao S, Shi Q, Zhang Y, Liang G, Kang Z, Huang B, Ma D, Wang L, Jiao J, Fang X, Xu CR, Liu L, Xu X, Göttgens B, Li C, Liu F. “Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics” Cell Res. 2021 Aug 2.
• Liang G, Zhou C, Jiang X, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B, Wang H, Han JJ, Liu F. “De novo generation of macrophage from placenta-derived hemogenic endothelium” Dev Cell. 2021 Jul 26
• Barile M, Imaz-Rosshandler I, Inzani I, Ghazanfar S, Nichols J, Marioni JC, Guibentif C, Göttgens B. “Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation” Genome Biol. 2021 Jul 5
• Oedekoven CA, Belmonte M, Bode D, Hamey FK, Shepherd MS, Che JLC, Boyd G, McDonald C, Belluschi S, Diamanti E, Bastos HP, Bridge KS, Göttgens B, Laurenti E, Kent DG. “Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures” Stem Cell Reports. 2021 Jun 8
• Thoms JAI, Truong P, Subramanian S, Knezevic K, Harvey G, Huang Y, Seneviratne JA, Carter DR, Joshi S, Skhinas J, Chacon D, Shah A, de Jong I, Beck D, Gottgens B, Larsson J, Wong JWH, Zanini F, Pimanda JE. “Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells” Blood. 2021 Jun 1
• Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan MD, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolić MZ, Duncan CJA, Smith KGC, Teichmann SA, Clatworthy MR, Marioni JC, Göttgens B, Haniffa M. “Single-cell multi-omics analysis of the immune response in COVID-19” Nat Med. 2021 Apr 20
• Takahashi M, Barile M, Chapple RH, Tseng YJ, Nakada D, Busch K, Fanti AK, Säwén P, Bryder D, Höfer T, Göttgens B. “Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics” Stem Cell Reports. 2021 Apr 13
• Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A, Timms P, Carter RN, Allen L, Campos J, Vukovic M, Guitart AV, Giles P, O’Shea M, Vernimmen D, Morton NM, Rodrigues NP, Göttgens B, Schofield CJ, Lengeling A, O’Carroll D, Kranc KR. “JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells” Blood Adv. 2021 Feb 9
• Harland LTG, Simon CS, Senft AD, Costello I, Greder L, Imaz-Rosshandler I, Göttgens B, Marioni JC, Bikoff EK, Porcher C, de Bruijn MFTR, Robertson EJ. The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors” Nat Cell Biol. 2021 Jan;23
• Wang X, Peticone C, Kotsopoulou E, Göttgens B, Calero-Nieto FJ. “Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures” Oncoimmunology. 2021 Jan 6
• Rothenberg EV, Göttgens B. “How haematopoiesis research became a fertile ground for regulatory network biology as pioneered by Eric Davidson” Curr Opin Hematol. 2021 Jan;28
• Dingler FA, Wang M, Mu A, Millington CL, Oberbeck N, Watcham S, Pontel LB, Kamimae-Lanning AN, Langevin F, Nadler C, Cordell RL, Monks PS, Yu R, Wilson NK, Hira A, Yoshida K, Mori M, Okamoto Y, Okuno Y, Muramatsu H, Shiraishi Y, Kobayashi M, Moriguchi T, Osumi T, Kato M, Miyano S, Ito E, Kojima S, Yabe H, Yabe M, Matsuo K, Ogawa S, Göttgens B, Hodskinson MRG, Takata M, Patel KJ. “Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans” Mol Cell. 2020 Dec 17
• Guibentif C, Griffiths JA, Imaz-Rosshandler I, Ghazanfar S, Nichols J, Wilson V, Göttgens B, Marioni JC. “Diverse Routes toward Early Somites in the Mouse Embryo” Dev Cell. 2020 Dec 1
• Haltalli MLR, Watcham S, Wilson NK, Eilers K, Lipien A, Ang H, Birch F, Anton SG, Pirillo C, Ruivo N, Vainieri ML, Pospori C, Sinden RE, Luis TC, Langhorne J, Duffy KR, Göttgens B, Blagborough AM, Lo Celso C. “Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection” Nat Cell Biol. 2020 Dec 22
• Kucinski I, Wilson NK, Hannah R, Kinston SJ, Cauchy P, Lenaerts A, Grosschedl R, Göttgens B. “Interactions between lineage-associated transcription factors govern haematopoietic progenitor states” EMBO J. 2020 Oct 26
• Hamey FK, Lau WWY, Kucinski I, Wang X, Diamanti E, Wilson NK, Göttgens B, Dahlin JS. “Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development” Allergy. 2020 Oct 20
• Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI. “CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation” Proc Natl Acad Sci U S A. 2020 Sep 22
• Göttgens B. “Introduction to a review series on mechanisms and clinical implications of clonal hematopoiesis” Blood. 2020 Oct 1
• Ton MN, Guibentif C, Göttgens B. “Single cell genomics and developmental biology: moving beyond the generation of cell type catalogues” Curr Opin Genet Dev. 2020 Oct
• Numata A, Kwok HS, Zhou QL, Li J, Tirado-Magallanes R, Espinosa Angarcia V, Hannah RL, Park J, Wang CQ, Krishnan V, Rajagopalan D, Zhang Y, Zhou S, Welner R, Osato M, Jha S, Bohlander SK, Göttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG, “Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance” Blood. 2020 Jun 15
• Vink CS, Calero-Nieto FJ, Wang X, Maglitto A, Mariani SA, Jawaid W, Göttgens B, Dzierzak E, “Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells” Cell Rep. 2020 May 12
• Park JE, Jardine L, Gottgens B, Teichmann SA, Haniffa M, “Prenatal development of human immunity” Science. 2020 May 8
• Dong F, Hao S, Zhang S, Zhu C, Cheng H, Yang Z, Hamey FK, Wang X, Gao A, Wang F, Gao Y, Dong J, Wang C, Wang J, Lan Y, Liu B, Ema H, Tang F, Göttgens B, Zhu P, Cheng T, “Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis” Nat Cell Biol. 2020 Jun
• Koth J, Wang X, Killen AC, Stockdale WT, Potts HG, Jefferson A, Bonkhofer F, Riley PR, Patient RK, Göttgens B, Mommersteeg MTM, “Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration” Development. 2020 Apr 27
• Pijuan-Sala B, Wilson NK, Xia J, Hou X, Hannah RL, Kinston S, Calero-Nieto FJ, Poirion O, Preissl S, Liu F, Göttgens B, “Single-cell Chromatin Accessibility Maps Reveal Regulatory Programs Driving Early Mouse Organogenesis” Nat Cell Biol. 2020 Apr
• Basilico S, Wang X, Kennedy A, Tzelepis K, Giotopoulos G, Kinston SJ, Quiros PM, Wong K, Adams DJ, Carnevalli LS, Huntly BJP, Vassiliou GS, Calero-Nieto FJ, Göttgens B, “Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML” Nat Commun. 2020 Mar 16
• Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A “Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation” EMBO J. 2020 Apr
• Xiang G, Keller CA, Heuston E, Giardine BM, An L, Wixom AQ, Miller A, Cockburn A, Sauria MEG, Weaver K, Lichtenberg J, Göttgens B, Li Q, Bodine D, Mahony S, Taylor J, Blobel GA, Weiss MJ, Cheng Y, Yue F, Hughes J, Higgs DR, Zhang Y, Hardison RC “An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis” Genome Res. 2020 Mar
• Kucinski I, Gottgens B, “Advancing Stem Cell Research through Multimodal Single-Cell Analysis” Cold Spring Harb Perspect Biol. 2020 Jan 13
• Fukushima T, Tanaka Y, Hamey FK, Chang CH, Oki T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Umemoto T, Takubo K, Takizawa H, Goyama S, Ishihama Y, Honda H, Göttgens B, Kitamura T, “Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium” Cell Rep. 2019 Dec 17
• Argelaguet R, Clark SJ, Mohammed H, Stapel LC, Krueger C, Kapourani CA, Imaz-Rosshandler I, Lohoff T, Xiang Y, Hanna CW, Smallwood S, Ibarra-Soria X, Buettner F, Sanguinetti G, Xie W, Krueger F, Göttgens B, Rugg-Gunn PJ, Kelsey G, Dean W, Nichols J, Stegle O, Marioni JC, Reik W, “Multi-omics profiling of mouse gastrulation at single-cell resolution” Nature. 2019 Dec
• Barral A, Rollan I, Sanchez-Iranzo H, Jawaid W, Badia-Careaga C, Menchero S, Gomez MJ, Torroja C, Sanchez-Cabo F, Göttgens B, Manzanares M, Sainz de Aja J, “Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation” Biol Open. 2019 Dec 2
• Hardison RC, Zhang Y, Keller CA, Xiang G, Heuston EF, An L, Lichtenberg J, Giardine BM, Bodine D, Mahony S, Li Q, Yue F, Weiss MJ, Blobel GA, Taylor J, Hughes J, Higgs DR, Göttgens B, “Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells” IUBMB Life. 2020 Jan
• Gambardella L, McManus SA, Moignard V, Sebukhan D, Delaune A, Andrews S, Bernard WG, Morrison MA, Riley PR, Göttgens B, Gambardella Le Novère N, Sinha S, “BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium” Development. 2019 Dec 13
• Vijayabaskar MS, Goode DK, Obier N, Lichtinger M, Emmett AML, Abidin FNZ, Shar N, Hannah R, Assi SA, Lie-A-Ling M, Gottgens B, Lacaud G, Kouskoff V, Bonifer C, Westhead DR, “Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets” PLoS Comput Biol. 2019 Nov 4
• Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne H, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T, “Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia” Cancer Discov. 2019 Oct 29.
• Fitch SR, Kapeni C, Tsitsopoulou A, Wilson NK, Göttgens B, de Bruijn MF, Ottersbach K, “Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche” IUBMB Life. 2019 Oct 21.
• Popescu DM, Botting RA, Stephenson E, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M, Acres M, Maunder D, Vegh P, Gitton Y, Park JE, Vento-Tormo R, Miao Z, Dixon D, Rowell R, McDonald D, Fletcher J, Poyner E, Reynolds G, Mather M, Moldovan C, Mamanova L, Greig F, Young MD, Meyer KB, Lisgo S, Bacardit J, Fuller A, Millar B, Innes B, Lindsay S, Stubbington MJT, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Filby A, Carey P, Villani AC, Roy A, Regev A, Chédotal A, Roberts I, Göttgens B, Behjati S, Laurenti E, Teichmann SA, Haniffa M, “Decoding human fetal liver haematopoiesis” Nature. 2019 Oct 9.
• Sasca D, Yun H, Giotopoulos G, Szybinski J, Evan T, Wilson NK, Gerstung M, Gallipoli P, Green AR, Hills RK, Russell NH, Osborne CS, Papaemmanuil E, Gottgens B, Campbell PJ, Huntly BJP, “Cohesin-dependent regulation of gene expression during differentiation is lost in Cohesin-mutated myeloid malignancies” Blood. 2019 Sep 12
• Hamey FK, Göttgens B, “Machine learning predicts putative haematopoietic stem cells within large single-cell transcriptomics datasets” Exp Hematol. 2019 Sep 9.
• Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR “Distinct Molecular Trajectories Converge to Induce Naive Pluripotency” Cell Stem Cell. 2019 Sep 5.
• Castaño J, Aranda S, Bueno C, Calero-Nieto FJ, Mejia-Ramirez E, Mosquera JL, Blanco E, Wang X, Prieto C, Zabaleta L, Mereu E, Rovira M, Jiménez-Delgado S, Matson DR, Heyn H, Bresnick EH, Göttgens B, Di Croce L, Menendez P, Raya A, Giorgetti A “GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm” Stem Cell Reports. 2019 Sep 10.
• Wilkinson AC, Ryan DJ, Kucinski I, Wang W, Yang J, Nestorowa S, Diamanti E, Tsang JC, Wang J, Campos LS, Yang F, Fu B, Wilson N, Liu P, Gottgens B, “Expanded potential stem cell media as a tool to study human developmental hematopoiesis in vitro” Exp Hematol. 2019 Aug.
• Prior N, Hindley CJ, Rost F, Meléndez E, Lau WWY, Göttgens B, Rulands S, Simons BD, “Huch M,Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool” Development. 2019 Jun 12
• Hamey FK, Göttgens B, “Reconstructing Gene Regulatory Networks That Control Hematopoietic Commitment” Methods Mol Biol. 2019.
• Kalna V, Yang Y, Peghaire CR, Frudd K, Hannah R, Shah AV, Osuna Almagro L, Boyle JJ, Göttgens B, Ferrer J, Randi AM, Birdsey GM, “The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program” Circ Res. 2019 Apr 26.
• Wolf FA, Hamey FK, Plass M, Solana J, Dahlin JS, Göttgens B, Rajewsky N, Simon L, Theis FJ, “PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells” Genome Biol. 2019 Mar 19.
• Sainz de Aja J, Menchero S, Rollan I, Barral A, Tiana M, Jawaid W, Cossio I, Alvarez A, Carreño-Tarragona G, Badia-Careaga C, Nichols J, Göttgens B, Isern J, Manzanares M, “The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1” EMBO J. 2019 Apr 1.
• Pijuan-Sala B, Griffiths JA, Guibentif C, Hiscock TW, Jawaid W, Calero-Nieto FJ, Mulas C, Ibarra-Soria X, Tyser RCV, Ho DLL, Reik W, Srinivas S, Simons BD, Nichols J, Marioni JC, Göttgens B, “A single-cell molecular map of mouse gastrulation and early organogenesis” Nature. 2019 Feb.
• Watcham S, Kucinski I, Göttgens B, “New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing” Blood 2019 Feb 6.
• Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambilet D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Göttgens B, Marschalek R, Menendez P, “Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions”  Haematologica 2019 Jan 24.
• Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, Bonfanti P, Göttgens B, Huch M, Simons B, Philpott A, “Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells” Sci Rep. 2018 Oct 18
• Belluschi S, Calderbank EF, Ciaurro V, Pijuan-Sala B, Santoro A, Mende N, Diamanti E, Sham KYC, Wang X, Lau WWY, Jawaid W, Göttgens B, Laurenti E, “Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors”Nat Commun. 2018 Oct 5
• Kauts ML, De Leo B, Rodríguez-Seoane C, Ronn R, Glykofrydis F, Maglitto A, Kaimakis P, Basi M, Taylor H, Forrester L, Wilkinson AC, Göttgens B, Saunders P, Dzierzak E, “Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells”  Epub 2018 Sep 6
• Richard AC, Lun ATL, Lau WWY, Göttgens B, Marioni JC, Griffiths GM, “T cell cytolytic capacity is independent of initial stimulation strength” Nat Immunol 2018 Aug
• Shepherd MS, Li J, Wilson NK, Oedekoven CA, Li J, Belmonte M, Fink J, Prick JCM, Pask DC, Hamilton TL, Loeffler D, Rao A, Schröder T, Göttgens B, Green AR, Kent DG, “Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal” Blood 2018 Aug 23
• Sznurkowska MK, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley CJ, Nichols J, Göttgens B, Huch M, Philpott A, Simons BD, “Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development” Dev Cell 2018 Aug 6
• Gozdecka M, Meduri E, Mazan M, Tzelepis K, Dudek M, Knights AJ, Pardo M, Yu L, Choudhary JS, Metzakopian E, Iyer V, Yun H, Park N, Varela I, Bautista R, Collord G, Dovey O, Garyfallos DA, De Braekeleer E, Kondo S, Cooper J, Göttgens B, Bullinger L, Northcott PA, Adams D, Vassiliou GS, Huntly BJP, “UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs” Nat Genet 2018 Jun
• Pijuan-Sala B, Guibentif C, Göttgens B, “Single-cell transcriptional profiling: a window into embryonic cell-type specification” Nat Rev Mol Cell Biol 2018 Jun
• Woodhouse S, Piterman N, Wintersteiger CM, Göttgens B, Fisher J, ” SCNS: a graphical tool for reconstructing executable regulatory networks from single-cell genomic data” BMC Syst Biol 2018 May 25
• Dahlin JS, Hamey FK, Pijuan-Sala B, Shepherd M, Lau WWY, Nestorowa S, Weinreb C, Wolock S, Hannah R, Diamanti E, Kent DG, Göttgens B, Wilson NK, “A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice” Blood 2018 May 24
• Hamey FK, Göttgens B, “Sorting apples from oranges in single-cell expression comparisons” Nat Methods 2018 Apr 27
• Lescroart F, Wang X, Lin X, Swedlund B, Gargouri S, Sànchez-Dànes A, Moignard V, Dubois C, Paulissen C, Kinston S, Göttgens B, Blanpain C, “Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq” Science 2018 Mar 9
• Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, Jörg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, Göttgens B, Marioni JC, “Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation” Nat Cell Biol 2018 Feb
• Laurenti E, Göttgens B, “From haematopoietic stem cells to complex differentiation landscapes” Nature 2018 Jan 24
• Karamitros D, Stoilova B, Aboukhalil Z, Hamey F, Reinisch A, Samitsch M, Quek L, Otto G, Repapi E, Doondeea J, Usukhbayar B, Calvo J, Taylor S, Goardon N, Six E, Pflumio F, Porcher C, Majeti R, Göttgens B, Vyas P, “Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells” Nat Immunol 2018 Jan
• Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe’er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N; Human Cell Atlas Meeting Participants, “The Human Cell Atlas” Elife 2017 Dec 5
• Wahlestedt M, Ladopoulos V, Hidalgo I, Sanchez Castillo M, Hannah R, Säwén P, Wan H, Dudenhöffer-Pfeifer M, Magnusson M, Norddahl GL, Göttgens B, Bryder D, “Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor” Cell Rep 2017 Nov 21
• Wilkinson AC, Nakauchi H, Göttgens B, “Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity” Cell Syst 2017 Oct 25
• Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM, “Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine” Mol Metab 2017 Oct;6(10):1296-1303.
• Lun ATL, Calero-Nieto FJ, Haim-Vilmovsky L, Göttgens B, Marioni JC, “Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data” Genome Res. 2017 Oct 13.
• Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P, “Establishment of mouse expanded potential stem cells” Nature 2017 Oct 11.
• Loughran SJ, Comoglio F, Hamey FK, Giustacchini A, Errami Y, Earp E, Göttgens B, Jacobsen SEW, Mead AJ, Hendrich B, Green AR “Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program” J Exp Med 2017 Oct 2;214(10):3085-3104
• Hamey FK, Nestorowa S, Kinston SJ, Kent DG, Wilson NK, Göttgens B, “Reconstructing blood stem cell regulatory network models from single-cell molecular profiles” Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5822-5829. Guibentif C, Göttgens B, Blood: Education for stem cells” Nature 2017 May 25;545(7655):415-417.
• Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A “Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation” Dev Cell 2017 May 8;41(3):274-286.e5.
• Basilico S, Göttgens B, “Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia” J Mol Med (Berl) 2017 Jul;95(7):719-727.
  Hamey FK, Göttgens B, “Demystifying blood stem cell fates” Nat Cell Biol 2017 Mar 31;19(4):261-263. doi: 10.1038/ncb3494.
• Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E, “Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis” Nature 2017 Apr 6;544(7648):53-58.
• Silverbush D, Grosskurth S, Wang D, Powell F, Gottgens B, Dry J, Fisher J, “Cell-specific computational modeling of the PIM pathway in acute myeloid leukemia” Cancer Res 2016 Dec 13. pii: canres.1578.2016.
• Ng FS, Ruau D, Wernisch L, Göttgens B, “A graphical model approach visualizes regulatory relationships between genome-wide transcription factor binding profiles” Brief Bioinform 2016 Oct 25. pii: bbw102.
• Moignard V, Göttgens B, “Dissecting stem cell differentiation using single cell expression profiling” Curr Opin Cell Biol 2016 Dec;43:78-86. doi: 10.1016/j.ceb.2016.08.005.
• Cañete A, Comaills V, Prados I, Castro AM, Hammad S, Ybot-Gonzalez P, Bockamp E, Hengstler JG, Gottgens B, Sánchez MJ, “Characterization of a Fetal Liver Cell Population Endowed with Long-Term Multi-Organ Endothelial Reconstitution Potential” Stem Cells 2016 Sep 12. doi: 10.1002/stem.2494.
• Lim CY, Wang H, Woodhouse S, Piterman N, Wernisch L, Fisher J, Göttgens B, “BTR: training asynchronous Boolean models using single-cell expression data” BMC Bioinformatics 2016 Sep 6;17(1):355. doi: 10.1186/s12859-016-1235-y
• Nasrallah R, Fast EM, Solaimani P, Knezevic K, Eliades A, Patel R, Thambyrajah R, Unnikrishnan A, Thoms J, Beck D, Vink CS, Smith A, Wong J, Shepherd M, Kent D, Roychoudhuri R, Paul F, Klippert J, Hammes A, Willnow T, Göttgens B, Dzierzak E, Zon LI, Lacaud G, Kouskoff V, Pimanda JE, “Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes” Blood 2016 Aug 23. pii: blood-2016-02-697870.
• Ezer D, Moignard V, Göttgens B, Adryan B “Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data” PLoS Comput Biol 2016 Aug 23;12(8):e1005072.
• Scialdone A, Tanaka Y, Jawaid W, Moignard V, Wilson NK, Macaulay IC, Marioni JC, Göttgens B, “Resolving early mesoderm diversification through single-cell expression profiling” Nature 2016 Jul 6;535(7611):289-93. doi: 10.1038/nature18633.
• Nestorowa S, Hamey FK, Pijuan Sala B, Diamanti E, Shepherd M, Laurenti E, Wilson NK, Kent DG, Göttgens B, “A single cell resolution map of mouse haematopoietic stem and progenitor cell differentiation” Blood 2016 Jun 30. pii: blood-2016-05-716480.
• Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA, “DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias” Cancer Cell 2016 Jun 13;29(6):922-34. doi: 10.1016/j.ccell.2016.05.003.
• Hamey FK, Nestorowa S, Wilson NK, Göttgens B, “Advancing haematopoietic stem and progenitor cell biology through single cell profiling” FEBS Lett 2016 Jun 4. doi: 10.1002/1873-3468.12231.
• Goode DK, Obier N, Vijayabaskar MS, Lie-A-Ling M, Lilly AJ, Hannah R, Lichtinger M, Batta K, Florkowska M, Patel R, Challinor M, Wallace K, Gilmour J, Assi SA, Cauchy P, Hoogenkamp M, Westhead DR, Lacaud G, Kouskoff V, Göttgens B, Bonifer C, “Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation” Dev Cell 2016 Mar 7;36(5):572-87
• Schütte J, Wang H, Antoniou S, Jarratt A, Wilson NK, Riepsaame J, Calero-Nieto FJ, Moignard V, Basilico S, Kinston SJ, Hannah RL, Chan MC, Nürnberg ST, Ouwehand WH, Bonzanni N, de Bruijn MF, Göttgens B, “An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability” Elife 2016 Feb 22;5. pii: e11469
• Wilson NK, Schoenfelder S, Hannah R, Sánchez Castillo M, Schütte J, Ladopoulos V, Mitchelmore J, Goode DK, Calero-Nieto FJ, Moignard V, Wilkinson AC, Jimenez-Madrid I, Kinston S, Spivakov M, Fraser P, Göttgens B, “Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model” Blood 2016 Jan 25. pii: blood-2015-10-677393
• Lelieveld SH, Schütte J, Dijkstra MJ, Bawono P, Kinston SJ, Göttgens B, Heringa J, Bonzanni N, “ConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sites” Nucleic Acids Res 2015 Dec 31. pii: gkv1518
• Park HJ, Li J, Hannah R, Biddie S, Leal-Cervantes AI, Kirschner K, Flores Santa Cruz D, Sexl V, Göttgens B, Green AR, “Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program” EMBO J 2015 Dec 23. pii: e201592383
• Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G, “GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.” Nat Cell Biol 2016 Jan;18(1):21-32
• Woodhouse S, Moignard V, Göttgens B, Fisher J, “Processing, visualising and reconstructing network models from single-cell data” Immunol Cell Biol 2015 Nov 18
• Bonadies N, Göttgens B, Calero-Nieto FJ, “The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity” PLoS One 2015 Jul 10;10(7):e0131577
• Sive JI, Basilico S, Hannah R, Kinston SJ, Calero-Nieto FJ, Göttgens B, “Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia” Leukemia 2015 Jul 1
• Watson JK, Rulands S, Wilkinson AC, Wuidart A, Ousset M, Van Keymeulen A, Göttgens B, Blanpain C, Simons BD, Rawlins EL, “Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium” Cell Rep 2015 Jul 7;12(1):90-101
• Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B, Passegué E, “Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions” Cell Stem Cell 2015 Jul 2;17(1):35-46
• Wilson NK, Kent DG, Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B, “Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations” Cell Stem Cell 2015 Jun 4;16(6):712-24
• Göttgens B, “Regulatory network control of blood stem cells” Blood 2015 Apr 23;125(17):2614-20
• Lau WW, Hannah R, Green AR, Göttgens B, “The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients” Blood 2015 Mar 5;125(10):1679-81
• Göttgens B, “Creating cellular diversity through transcription factor competition” EMBO J 2015 Mar 12;34(6):691-3
• Moignard V, Woodhouse S, Haghverdi L, Lilly AJ, Tanaka Y, Wilkinson AC, Buettner F, Macaulay IC, Jawaid W, Diamanti E, Nishikawa S, Piterman N, Kouskoff V, Theis FJ, Fisher J, Göttgens B, “Decoding the regulatory network of early blood development from single-cell gene expression measurements” Nat Biotechnol 2015 Mar;33(3):269-76
• Ng FS, Schütte J, Ruau D, Diamanti E, Hannah R, Kinston SJ, Göttgens B, “Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells” Nucleic Acids Res 2014 Dec 16;42(22):13513-24
• Ng FS, Calero-Nieto FJ, Göttgens B, “Shared transcription factors contribute to distinct cell fates” Transcription 2014;5(5):e978173
• Sánchez-Castillo M, Ruau D, Wilkinson AC, Ng FS, Hannah R, Diamanti E, Lombard P, Wilson NK, Göttgens B, “CODEX: a next-generation sequencing experiment database for the haematopoietic and embryonic stem cell communities” Nucleic Acids Res 2015 Jan;43(Database issue):D1117-23.
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