Research focus
Keywords: Stem cells, progenitor cells, haematopoiesis, genome wide molecular approaches
Clinical conditions: Acute myeloid leukaemia
Methodologies: Isolating rare stem and progenitor cells, genome wide profiling, functional assays
Professor of Stem Cells and Haematopoiesis
Description of research
Life long production of all blood cell types is guaranteed by haematopoietic stem cells (HSC) through their ability to give rise to other HSC (self-renewal) as well as progressively more restricted cell types (differentiation). HSC are the best characterised stem cell type, owing to decades of intensive studies almost exclusively in model systems. These studies have revealed many stem cell properties, such as their infrequent division (quiescence) and have highlighted cellular and molecular routes that lead to the formation of mature blood cell types. It is almost taken for granted that what is true in small mammals will be conserved in humans. However differences in size, metabolism and longevity between human and animal models impose different demands on the blood system and suggest that there may be species-specific characteristics of HSC. Identifying these differences is a very important step to translate basic research findings to the clinic. Thus, the Laurenti group research focuses on primary human haematopoietic samples. Our goal is to understand the unique functional properties and molecular circuits of human HSC and how these are perturbed in disease.
Human HSC functional properties and their transcriptional make-up are unique compared to that of other hematopoietic cell types. When HSC differentiate into more committed progenitors, there are gradual changes in gene expression that translate into distinct usage of signalling routes, metabolic pathways, cell cycle properties (Nature Immunology 2013) and unfolded protein response (Nature 2014). Altogether these molecular circuits endow HSC with unique functional properties compared to their immediate progeny. Human HSC also seem to have evolved mechanisms subtly distinct from that of other species to ensure life-long blood production. In particular in injury or stress related contexts, the molecular basis for these processes is currently unknown. By using genome-wide profiling and functional assays, we aim to identify the changes, molecular and functional, triggered by stresses that these HSC are exposed to, both physiologically and in pathological conditions. This is part of an ongoing effort to understand the molecular networks of human HSC in homeostatic (Nature Immunology) and stress conditions.
Our particular areas of interest are:
- Understanding how quiescence is maintained in normal HSC.
- Understanding how HSC commit to a particular lineage.
- Defining how human HSC respond to stress.
As perturbations of the normal responses to these factors are considered stepping stones for leukaemogenesis, knowledge of these HSC specific responses to stress will prove important to understand how leukaemia arises.
If you are interested in working with us, please contact us at el422@cam.ac.uk. We are always looking for smart motivated people to join our team.
Key Publications
Poon G, Vedi A, Sanders M, Laurenti E, Valk P, Blundell JR. Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution. Cell Genom. 2025 Feb 12;5(2):100744
Conrad C, Magnen M, Tsui J, Wismer HJ, Naser M, Venkataramani U, Samad B, Cleary SJ, Qiu L, Tian JJ, De Giovanni M, Mende N, Leavitt AD, Passegue E, Laurenti E, Combes AJ, Looney MR. Decoding functional hematopoietic progenitor cells in the adult human lung. Blood. 2025 Feb 27:blood.2024027884.
Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre MA, Ranzoni AM, Robinson PS, Kregar LD, Wilk M, Boettcher S, Mahbubani K, Saeb Parsy K, Gowers KHC, Janes SM, Ng SWK, Hoare M, Green AR, Vassiliou GS, Cvejic A, Manz MG, Laurenti E, Martincorena I, Stratton MR, Nangalia J, Coorens THH, Campbell PJ. Prolonged persistence of mutagenic DNA lesions in somatic cells. Nature. 2025 Feb;638(8051):729-738.
Santarsieri A, Mitchell E, Pham MH, Sanghvi R, Jablonski J, Lee-Six H, Sturgess K, Brice P, Menne TF, Osborne W, Creasey T, Ardeshna KM, Baxter J, Behan S, Bhuller K, Booth S, Chavda ND, Collins GP, Culligan DJ, Cwynarski K, Davies A, Downing A, Dutton D, Furtado M, Gallop-Evans E, Hodson A, Hopkins D, Hsu H, Iyengar S, Jones SG, Karanth M, Linton KM, Lomas OC, Martinez-Calle N, Mathur A, McKay P, Nagumantry SK, Phillips EH, Phillips N, Rudge JF, Shah NK, Stafford G, Sternberg A, Trickey R, Uttenthal BJ, Wetherall N, Zhang XY, McMillan AK, Coleman N, Stratton MR, Laurenti E, Borchmann P, Borchmann S, Campbell PJ, Rahbari R, Follows GA. The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study. Lancet Oncol. 2025 Jan;26(1):98-109.
Williams MJ, Wang X, Bastos HP, Grondys-Kotarba G, Wu Q, Jin S, Johnson CS, Mende N, Calderbank EF, Wantoch M, Park HJ, Mantica G, Hannah RL, Wilson NK, Pask DC, Hamilton TL, Kinston SJ, Asby R, Sneade R, Baxter EJ, Campbell PJ, Vassiliou GS, Laurenti E, Li J, Gottgens B, Green AR. Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition. Blood Adv. 2024 Oct 7:bloodadvances.2024014046.
Johnson CS, Williams MJ, Sham K, Belluschi S, Ma W, Wang X, Lau WW, Kaufmann K, Krivdova G, Calderbank EF, Mende N, McLeod J, Mantica G, Li J, Grey-Wilson C, Drakopoulos M, Basheer S, Sinha S, Diamanti E, Basford C, Wilson NK, Howe SJ, Dick JE, Gottgens B, Green AR, Francis N, Laurenti E. Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of cell cycle. Blood. 2024 Aug 15;144(7):729-741.
Calderbank EF, Magnani L, Laurenti E. Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice. J Vis Exp. 2023 Dec 8;(202).
Liang KL, Laurenti E, Taghon T. Circulating IRF8-expressing CD123+CD127+ lymphoid progenitors: key players in human hematopoiesis. Trends Immunol. 2023 Sep;44(9):678-692.
Thomas JR, Appios A, Calderbank EF, Yoshida N, Zhao X, Hamilton RS, Moffett A, Sharkey A, Laurenti E, Hanna CW, McGovern N. Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR. Nat Commun. 2023 Mar 30;14(1):1764.
Li J, Williams MJ, Park HJ, Bastos HP, Wang X, Prins D, Wilson NK, Johnson C, Sham K, Wantoch M, Watcham S, Kinston SJ, Pask DC, Hamilton TL, Sneade R, Waller AK, Ghevaert C, Vassiliou GS, Laurenti E, Kent DG, Göttgens B, Green AR. STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion. Blood. 2022 Oct 6;140(14):1592-1606.
Machado HE, Mitchell E, Øbro NF, Kübler K, Davies M, Leongamornlert D, Cull A, Maura F, Sanders MA, Cagan ATJ, McDonald C, Belmonte M, Shepherd MS, Vieira Braga FA, Osborne RJ, Mahbubani K, Martincorena I, Laurenti E, Green AR, Getz G, Polak P, Saeb-Parsy K, Hodson DJ, Kent DG, Campbell PJ. Diverse mutational landscapes in human lymphocytes. Nature. 2022 Aug;608(7924):724-732.
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells. Nat Cell Biol. 2022 Jul;24(7):1038-1048.
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans. Blood. 2022 Jun 9;139(23):3387-3401.
Clonal dynamics of haematopoiesis across the human lifespan. Nature. 2022 Jun;606(7913):343-350. *Joint senior authors.
Mende N, Laurenti E, Göttgens B, Wilson NK. Simultaneous Analysis of Single-Cell Transcriptomes and Cell Surface Protein Expression of Human Hematopoietic Stem Cells and Progenitors Using the 10x Genomics Platform. Methods Mol Biol. 2022;2386:189-201.
Mende N, Laurenti E. Hematopoietic stem and progenitor cells outside the bone marrow: where, when, and why. Exp Hematol. 2021 Dec;104:9-16.
Jardine L, Webb S, Goh I, Quiroga Londoño M, Reynolds G, Mather M, Olabi B, Stephenson E, Botting RA, Horsfall D, Engelbert J, Maunder D, Mende N, Murnane C, Dann E, McGrath J, King H, Kucinski I, Queen R, Carey CD, Shrubsole C, Poyner E, Acres M, Jones C, Ness T, Coulthard R, Elliott N, O’Byrne S, Haltalli MLR, Lawrence JE, Lisgo S, Balogh P, Meyer KB, Prigmore E, Ambridge K, Jain MS, Efremova M, Pickard K, Creasey T, Bacardit J, Henderson D, Coxhead J, Filby A, Hussain R, Dixon D, McDonald D, Popescu DM, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Regev A, Behjati S, Laurenti E, Wilson NK, Roy A, Göttgens B, Roberts I, Teichmann SA, Haniffa M. Blood and immune development in human fetal bone marrow and Down syndrome. Nature. 2021 Oct;598(7880):327-331.
Oedekoven CA, Belmonte M, Bode D, Hamey FK, Shepherd MS, Che JLC, Boyd G, McDonald C, Belluschi S, Diamanti E, Bastos HP, Bridge KS, Göttgens B, Laurenti E, Kent DG. Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures. Stem Cell Reports. 2021 Jun 8;16(6):1614-1628.
Choudry FA, Bagger FO, Macaulay IC, Farrow S, Burden F, Kempster C, McKinney H, Olsen LR, Huang N, Downes K, Voet T, Uppal R, Martin JF, Mathur A, Ouwehand WH, Laurenti E, Teichmann SA, Frontini M. Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment. J Thromb Haemost. 2021 May;19(5):1236-1249.
Abascal F, Harvey LMR, Mitchell E, Lawson ARJ, Lensing SV, Ellis P, Russell AJC, Alcantara RE, Baez-Ortega A, Wang Y, Kwa EJ, Lee-Six H, Cagan A, Coorens THH, Chapman MS, Olafsson S, Leonard S, Jones D, Machado HE, Davies M, Øbro NF, Mahubani KT, Allinson K, Gerstung M, Saeb-Parsy K, Kent DG, Laurenti E, Stratton MR, Rahbari R, Campbell PJ, Osborne RJ, Martincorena I. Somatic mutation landscapes at single-molecule resolution. Nature. 2021 Apr 28.
Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan MD, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolić MZ, Duncan CJA, Smith KGC, Teichmann SA, Clatworthy MR, Marioni JC, Göttgens B, Haniffa M. Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med. 2021 Apr 20.
Laurenti E. Blood stem cells SELect quiescence. Blood. 2020 Dec 24;136(26):2967-2968.
Santoro A, Andrei C, Bryant C, Calderbank E, Wray A, Baxter JE, Godfrey A, Laurenti E, Ringshausen I. Chronic lymphocytic leukemia increases the pool of peripheral blood hematopoietic stem cells and skews differentiation. Blood Adv. 2020 Dec 22;4(24):6310-6314.
Johnson C, Belluschi S, Laurenti E. Beyond “to divide or not to divide”: Kinetics matters in hematopoietic stem cells. Exp Hematol. 2020 Dec;92:1-10.e2.
Bond J, Krzywon A, Lhermitte L, Roumier C, Roggy A, Belhocine M, Kheirallah AA, Villarese P, Hypolite G, Garnache-Ottou F, Castaigne S, Boissel N, Asnafi V, Preudhomme C, Dombret H, Laurenti E, Macintyre E. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis. Leukemia. 2020 Jul 13.
Xie SZ, Garcia-Prat L, Voisin V, Ferrari R, Gan OI, Wagenblast E, Kaufmann KB, Zeng AGX, Takayanagi SI, Patel I, Lee EK, Jargstorf J, Holmes G, Romm G, Pan K, Shoong M, Vedi A, Luberto C, Minden MD, Bader GD, Laurenti E, Dick JE. Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal. Cell Stem Cell. 2019 Nov 7;25(5):639-653.e7.
Popescu DM, Botting RA, Stephenson E, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M, Acres M, Maunder D, Vegh P, Gitton Y, Park JE, Vento-Tormo R, Miao Z, Dixon D, Rowell R, McDonald D, Fletcher J, Poyner E, Reynolds G, Mather M, Moldovan C, Mamanova L, Greig F, Young MD, Meyer KB, Lisgo S, Bacardit J, Fuller A, Millar B, Innes B, Lindsay S, Stubbington MJT, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Filby A, Carey P, Villani AC, Roy A, Regev A, Chédotal A, Roberts I, Göttgens B, Behjati S, Laurenti E, Teichmann SA, Haniffa M. Decoding human fetal liver haematopoiesis. Nature. 2019 Oct;574(7778):365-371.
Lyne AM, Kent DG, Laurenti E, Cornils K, Glauche I, Perié L. A track of the clones: new developments in cellular barcoding. Exp Hematol. 2018 Dec;68:15-20.
Belluschi S, Calderbank EF, Ciaurro V, Pijuan-Sala B, Santoro A, Mende N, Diamanti E, Sham KYC, Wang X, Lau WWY, Jawaid W, Göttgens B, Laurenti E. Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors. Nat Commun. 2018 Oct 5;9(1):4100.
Lee-Six H, Øbro NF, Shepherd MS, Grossmann S, Dawson K, Belmonte M, Osborne RJ, Huntly BJP, Martincorena I, Anderson E, O’Neill L, Stratton MR, Laurenti E, Green AR, Kent DG, Campbell PJ. Population dynamics of normal human blood inferred from somatic mutations. Nature. 2018 Sep;561(7724):473-478.
Laurenti E, Göttgens B. From haematopoietic stem cells to complex differentiation landscapes. Nature. 2018 Jan 24;553(7689):418-426.
Horton SJ, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford-Rogers R, Rashid M, Clipson A, Chan WI, Sasca D, Yiangou L, Osaki H, Basheer F, Gallipoli P, Burrows N, Erdem A, Sybirna A, Foerster S, Zhao W, Sustic T, Petrunkina Harrison A, Laurenti E, Okosun J, Hodson D, Wright P, Smith KG, Maxwell P, Fitzgibbon J, Du MQ, Adams DJ, Huntly BJP. Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nat Cell Biol. 2017 Sep;19(9):1093-1104.
Laurenti E. Human megakaryocytes: finding the root. Blood. 2017 Jun 22;129(25):3277-3279
Farlik M, Halbritter F, Müller F, Choudry FA, Ebert P, Klughammer J, Farrow S, Santoro A, Ciaurro V, Mathur A, Uppal R, Stunnenberg HG, Ouwehand WH, Laurenti E, Lengauer T, Frontini M, Bock C. DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation. Cell Stem Cell. 2016 Dec 1;19(6):808-822.
Nestorowa S, Hamey FK, Pijuan Sala B, Diamanti E, Shepherd M, Laurenti E, Wilson NK, Kent DG, Göttgens B. A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation. Blood. 2016 Aug 25;128(8):e20-31.
Vedi A, Santoro A, Dunant CF, Dick JE, Laurenti E. Molecular landscapes of human hematopoietic stem cells in health and leukemia. Ann N Y Acad Sci. 2016 Apr;1370(1):5-14.
Notta F*, Zandi S*, Takayama N, Dobson S, Gan O, Wilson G, Kaufmann KB, McLeod J, Laurenti E, Dunant CF, McPherson JD, Stein LD, Dror Y, Dick JE. Distinct routes of lineage development reshape the human blood hierarchy across ontogeny. Science. 2016 Jan 8;351(6269):aab2116. *equal contribution
Laurenti E*, Frelin C*, Xie S*, Ferrari R, Dunant CF, Zandi S, Neumann A, Plumb I, Doulatov S, Chen J, April C, Fan JB, Iscove N, Dick JE. CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell. 2015 Mar 5;16(3):302-13. *equal contribution
Qiao W, Wang W, Laurenti E, Turinsky AL, Wodak SJ, Bader GD, Dick JE, Zandstra PW. Intercellular network structure and regulatory motifs in the human hematopoietic system. Mol Syst Biol. 2014 Jul 15;10:741.
Moti N, Malcolm T, Hamoudi R, Mian S, Garland G, Hook CE, Burke GA, Wasik MA, Merkel O, Kenner L, Laurenti E, Dick JE, Turner SD. Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene. 2015 Apr 2;34(14):1843-52.
Theocharides AP, Dobson SM, Laurenti E, Notta F, Voisin V, Cheng PY, Yuan JS, Guidos CJ, Minden MD, Mullighan CG, Torlakovic E, Dick JE. Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts. Leukemia. 2015 Jan;29(1):177-87.
van Galen P, Kreso A, Mbong N, Kent DG, Fitz-Maurice T, Chambers J, Xie S, Laurenti E, Hermans K, Eppert K, Marciniak SJ, Goodall JC, Green AG, Wouters BG, Wienholds E, Dick JE; The unfolded protein response governs integrity of the HSC pool during stress, Nature. 2014 Jun 12;510(7504):268-72.
Carnevalli L, Rahmig S, Scognamiglio R, Cabezas-Wallscheid N, Masuda K, Laurenti E, Jockel L, Erlacher M, Ley T, Pasparakis M, Essers M, Trumpp A, Mice lacking Granzyme B show improved HSC reconstitution and protection from chemotherapy and inflammatory stress. J Exp Med. 2014 May 5;211(5):769-79.
van Galen P, Kreso A, Wienholds E, Laurenti E, Eppert K, Lechman E, Mbong N, Hermans K, Dobson S, April C, Fan JF, Dick JE, Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion Cell Stem Cell, 2014 Jan 2; 14 (1):94-106.
Laurenti E, Doulatov S, Zandi S, Plumb I, Chen J, April C, Fan J-B , Dick JE, The transcriptional architecture of human hematopoiesis identies multilevel control of lymphoid commitment Nature Immunology, Jul; 14(7): 756-63.
Barde I, Marin-Florez RM, Rauwel B, Corsinotti A, Laurenti E, Verp S, Oner S, Marquis J, Kapopoulou A, Vanicek J, Trono D, A KRAB/KAP1-RNA interference cascade regulates erythropoiesis through the stage-specic control of mitophagy Science, Apr 19;340(6130):350-3.
Laurenti E, Dick JE, Molecular and functional characterization of early human hematopoiesis, Ann N Y Acad Sci, Ann N Y Acad Sci 2012 Aug;1266:68-71.
Doulatov S, Notta F,Laurenti E, Dick JE, Hematopoiesis: a human perspective, Cell Stem Cell, 2012 Feb 3;10(2):120-36.
Zhang J, Ding L, Holmfeldt L, [ ] Laurenti E [ ], Wilson R, Downing JR, Mullighan CG, The genetic basis of early T-cell precursor acute lymphoblastic leukaemia, Nature, 2012 Jan 11;481(7380):157-63.
Notta F*, Doulatov S*, Laurenti E, Poeppl A, Jurisica I, Dick JE, Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment, Science, 2011 Jul 8; 333(6039):218-21. *equal contribution
Barde I, Laurenti E, Verp S, Wiznerowicz M, Oner S, Viornery A, Galy A, Trumpp A, Trono D, Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease, Gene Therapy, 2011 Nov;18(11):1087-97.
Tesio M, Golan K, Corso S, Giordano S, Schajnovitz A, Vagima Y, Shivtiel S, Kalinkovich A, Buss EC, Caione L, Laurenti E, Shezen E, Itkin T, Kollet O, Gammaitoni L, Petit I, Trumpp A, Christensen J, Aglietta M, Piacibello W, Lapidot T, Enhanced c-Met activity promotes G-CSF induced mobilization of hematopoietic progenitor cells via ROS signaling, Blood, 2011 Jan 13; 117(2):419-28.
Laurenti E, Barde I, Verp S, Oner S, Wilson A, Quenneville S, Wiznerowicz M, MacDonald HR, Trono D, Trumpp A, Inducible gene and shRNA expression in resident hematopoietic stem cells in vivo, Stem Cells, 2010 Aug;28(8):1390-8.
Jiang W, Ferrero I, Laurenti E, Trumpp A, MacDonald HR, c-Myc controls the development of CD8aa TCRab intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent surviva, Blood, 2010 Jun 3; 115(22):4431-8.
Laurenti E, Wilson A, Trumpp A, Myc’s other life: stem cells and beyond, Curr Opin Cell Biol, 2009 Dec; 21(6):844-54.
Fiorini E, Merck E, Wilson A, Ferrero I, Jiang W, Koch U, Auderset F, Laurenti E, Tacchini-Cottier F, Pierres M, Radtke F, Luther SA, MacDonald HR, Dynamic regulationof Notch 1 and Notch 2 surface expression during T cell development and activation by novel monoclonal antibodies, J Immun, 2009 Dec 1; 183(11):7212-22.
Wilson A, Laurenti E, Trumpp A, Balancing dormant and self-renewing hematopoietic stem cells, Curr Opin Genet Dev, 2009 Oct; 19(5):461-8.
Van der Wath RC, Wilson A, Laurenti E, Trumpp A, Lio’ P, Label-retaining cell modelling and dynamical analysis support the dormant hematopoietic stem cell hypothesis, PLOS one, 2009; 4(9): e6972 doi:101371/journalpone0006972.
Barde I, Laurenti E, Verp S, Groner AC, Towne C, Padrun V, Aebischer P, Trumpp A, Trono D, Regulation of episomal gene expression by KRAB/KAP1-mediated histone modications, J Virol, 2009 Jun;83(11):5574-80.
Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID and Trumpp A, Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity, Cell Stem Cell, 2008 Dec 4;3(6):611-24.
Wilson A, Laurenti E, Oser G, van der Wath R, Blanco-Bose WE, Jaworski M, Oner S, Dunant CF, Eshkind L, Bockamp E, Lio P, MacDonald HR, Trumpp A, Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair, Cell, 2008, Dec 12;135(6):1118-29.
Wilson A, Oser GM, Jaworski M, Blanco-Bose WE, Laurenti E, Adolphe C, Essers MA, MacDonald HR, Trumpp A, Dormant and self-renewing hematopoietic stem cells and their niches, Ann N Y Acad Sci, 2007 Jun;1106:64-75.
Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D, The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo, Oncogene, 2004 Nov 11; 23(53):8688-94.