Department of Haematology

The University of Cambridge Department of Haematology is located at the Cambridge Biomedical Campus and the Wellcome Trust Genome Campus. It has laboratories in the Jeffrey Cheah Biomedical Centre, the Cambridge Institute for Medical Research, NHS Blood and Transplant Blood Centre and the Wellcome Sanger Institute. The Head of Department is Professor Brian Huntly.

The department has four main goals:

• To conduct internationally competitive biomedical research.
• To provide education in medical aspects of haematology to undergraduate scientists and medical students.
• To provide postgraduate education, largely through the provision of PhD students.
• To contribute to the clinical activities of the Addenbrooke's Department of Haematology.

Recent publications

Foster HR, Colzani M, Bouet G, Howard D, Di Buduo CA, Müller-Sienerth N, Waller AK, Sun Y, Davidenko N, Shepherd JH, Moreau T, Evans AL, Soprano PM, Parsons MEM, Sims YY, Arumugam M, Afshar-Saber W, Turro E, Maguire PB, Best SM, Cameron RE, Balduini A, Wright GJ, Ghevaert C. Production of platelets in vitro in functionalised 3-dimensional scaffolds mimicking the bone marrow niche. Haematologica. 2025 Apr 24. doi: 10.3324/haematol.2024.286758.

George BM, Eleftheriou M, Yankova E, Perr J, Chai P, Nestola G, Almahayni K, Evans S, Damaskou A, Hemberger H, Lebedenko CG, Rak J, Yu Q, Bapcum E, Russell J, Bagri J, Volk RF, Spiekermann M, Stone RM, Giotopoulos G, Huntly BJP, Baxter J, Camargo F, Liu J, Zaro BW, Vassiliou GS, Möckl L, de la Rosa J, Flynn RA, Tzelepis K. Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein. Nat Biotechnol. 2025 Apr 23. doi: 10.1038/s41587-025-02648-2.

Fioredda F, Spanoudakis M, Skokowa J, Tamary H, Farruggia P, Almeida A, Guardo D, Palmblad J, Höglund P, Touw IP, Zeidler C, Warren AJ, Csenar M, Skoetz N, Castagnola E, Ricci E, Dale DC, Newburger PE, Welte K, Papadaki HA, Dufour C. European guidelines on treatment and supportive measures in chronic neutropenias: A consensus between the European Hematology Association and the EuNet-INNOCHRON COST Action based on a systematic evidence review. Hemasphere. 2025 Apr 16;9(4):e70113. doi: 10.1002/hem3.70113.

Gozdecka M, Dudek M, Wen S, Gu M, Stopforth RJ, Rak J, Damaskou A, Grice GL, McLoughlin MA, Bond L, Wilson R, Giotopoulos G, Mahalingam Shanmugiah V, Bakar RB, Yankova E, Cooper JL, Narayan N, Horton SJ, Asby R, Pask DC, Mupo A, Duddy G, Marando L, Georgomanolis T, Carter P, Ramesh AP, Dunn WG, Barcena C, Gallipoli P, Yusa K, Petrovski S, Wright P, Quiros PM, Frezza C, Nathan JA, Kaser A, Kar S, Tzelepis K, Mitchell J, Fabre MA, Huntly BJP, Vassiliou GS. Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis. Nature. 2025 Apr 16. doi: 10.1038/s41586-025-08980-6.

Azami T, Theeuwes B, Nu Ton ML, Mansfield W, Harland L, Kinoshita M, Gottgens B, Nichols J. STAT3 signaling enhances tissue expansion during postimplantation mouse development. Cell Rep. 2025 Apr 5;44(4):115506. doi: 10.1016/j.celrep.2025.115506.

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA. RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. Cell. 2025 Apr 3;188(7):1878-1895.e25. doi: 10.1016/j.cell.2025.01.040.

Kamizela AE, Leongamornlert D, Williams N, Wang X, Nyamondo K, Dawson K, Spencer Chapman M, Guo J, Lee J, Mane K, Milne K, Green AR, Chevassut T, Campbell PJ, Ellinor PT, Huntly BJP, Baxter EJ, Nangalia J.Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia. Nature. 2025 Apr;640(8060):982-990. doi: 10.1038/s41586-025-08817-2.

Huntington JA, Reckless J, Polderdijk SGI, Hextall P, Baglin T. The preclinical profile of SerpinPC- a potential new treatment for hemophilia. Blood Adv. 2025 Mar 14:bloodadvances.2024015201. doi: 10.1182/bloodadvances.2024015201.

Cui B, Ai L, Lei M, Duan Y, Tang C, Zhang J, Gao Y, Li X, Zhu C, Zhang Y, Zhu X, Isobe T, Yang W, Göttgens B, Zhu P.Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia. Blood. 2025 Mar 13;145(11):1211-1224. doi: 10.1182/blood.2024025618.

Kapadia CD, Williams N, Dawson KJ, Watson C, Yousefzadeh MJ, Le D, Nyamondo K, Kodavali S, Cagan A, Waldvogel S, Zhang X, De La Fuente J, Leongamornlert D, Mitchell E, Florez MA, Sosnowski K, Aguilar R, Martell A, Guzman A, Harrison D, Niedernhofer LJ, King KY, Campbell PJ, Blundell J, Goodell MA, Nangalia J.Clonal dynamics and somatic evolution of haematopoiesis in mouse. Nature. 2025 Mar 5. doi: 10.1038/s41586-025-08625-8.

Tokolyi A, Persyn E, Nath AP, Burnham KL, Marten J, Vanderstichele T, Tardaguila M, Stacey D, Farr B, Iyer V, Jiang X, Lambert SA, Noell G, Quail MA, Rajan D, Ritchie SC, Sun BB, Thurston SAJ, Xu Y, Whelan CD, Runz H, Petrovski S, Gaffney DJ, Roberts DJ, Di Angelantonio E, Peters JE, Soranzo N, Danesh J, Butterworth AS, Inouye M, Davenport EE, Paul DS. The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes. Nat Genet. 2025 Mar;57(3):616-625. doi: 10.1038/s41588-025-02096-3.

Wen S, Kuri-Morales P, Hu F, Nag A, Tachmazidou I, Deevi SVV, Taiy H, Smith KR, Loesch DP, Burren OS, Dhindsa RS, Wasilewski S, Alegre-Díaz J, Berumen J, Emberson J, Torres JM, Collins R, Carss K, Wang Q, Petrovski S, Tapia-Conyer R, Fabre MA, Harper AR, Vassiliou GS, Mitchell J. Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis. Nat Genet. 2025 Mar;57(3):572-582. doi: 10.1038/s41588-025-02085-6.